LeakWeek 2023 Day Six: Treatment

June 9, 2023News

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Spinal CSF Leak Treatment

Treatment for spinal CSF leak varies from conservative measures to surgical procedures. Some patients have symptoms that resolve spontaneously in a matter of hours, days, or weeks without ever seeking or requiring medical care. However, some serious complications dictate emergent and more aggressive intervention.

Leak week 2023 treatment

Conservative measures

Conservative measures of managing symptoms while waiting for treatment include complete bedrest (the risk of deep vein thrombosis during periods of prolonged bed rest should be discussed with your treating physician); oral and/or intravenous hydration, including electrolytes; caffeine; wearing an abdominal binder when upright; and avoidance of Valsalva maneuver.

Epidural blood and/or glue patching

In an epidural blood patch (EBP), the patient’s own blood is injected into the epidural space (the space just outside the dura within the spinal canal), forming a “patch” over the dura. An EBP can be targeted (that is, placed at the known location where a patient is leaking, such as a post LP leak) or it can be non-targeted (placed at lumbar or thoracolumbar locations). A non-targeted EBP is usually performed when a leak site has not yet been localized, or for diagnostic purposes. The volume (the amount of the patient’s own blood administered) ranges from small (10 mL) to large (100 mL). When the leak location is known or suspected, epidural patching with fibrin glue sealant may be used.

While restrictions after an EBP are individualized, it is typical for physicians to recommend avoidance of bending, lifting, twisting, and straining (valsalva) for about 4-6 weeks.

Surgical treatment

Depending on the nature of the leak, surgical repair may be required. Surgical repairs are often less technically straightforward than might be anticipated, due to frequently noted abnormal dura and the variety of anatomic leak types and locations. The specific approach is tailored to the type and location of the leak and to the individual patient.

In cases where a spinal CSF leak is caused by a CSF-venous fistula, this can be treated by surgery, by glue injection, or by endovascular embolization.

After treatment: Rebound head pain

Following a treatment or surgical procedure, some people may notice a change in the nature of their head pain. This is sometimes referred to as Rebound Intracranial Hypertension. The literature suggests that 27% of patients experience rebound head pain, but this number is likely an underestimate.

The average duration of this rebound head pain is not well reported, but clinical consensus and limited case reports suggests that if symptoms and signs suggestive of intracranial hypertension progressively worsen beyond 14 days then clinical reassessment should be considered.

In this talk from the very first Cedars-Sinai Intracranial Hypotension Symposium sponsored by the Spinal CSF Leak Foundation, Dr. Peter Kranz and Dr. Wouter Schievink discuss RIH, its symptoms, and its management.

Another of our medical advisors, Dr. Deborah Friedman, spoke on the subject of RIH and IIH at the 2018 symposium. You can view the slides of her talk here.

Prognosis

Prognosis, from the Greek word meaning “foreknowledge,” means “the likely outcome or course of a disease.” And the prognosis for many patients with spinal CSF leak is favorable—but only when the diagnosis is recognized and appropriate treatment is offered.

There are some patients who continue to have persistent symptoms and associated disability despite numerous interventions, regardless of whether their spinal CSF leak is spontaneous or iatrogenic.