This talk by Heidi Collins, MD was posted by the Ehlers-Danlos National Foundation. Dr. Collins brilliantly describes the basics of connective tissues, heritable disorders of connective tissue and the broad range of manifestations in Ehlers-Danlos Syndrome (EDS).
Almost all patients with spontaneous spinal CSF leaks have weakened dura related to an underlying heritable disorder of connective tissue (HDCT). Ehlers-Danlos is one group of HDCTs found at a higher prevalence in those with spontaneous spinal CSF leaks.
This video is very worth your time to watch and learn more about connective tissue disorders and EDS.